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Normal Renin Uremic HypertensionStudy of Cardiac Hemodynamics, Plasma Volume, Extracellular Fluid Volume, and the Renin Angiotensin System
José L. Cangiano, MD;
Osvald Ramirez-Muxó, MD;
Rafael Ramirez-Gonzalez, MD;
Arturo Trevino, MD;
José A. Campos, MD
Arch Intern Med. 1976;136(1):17-23.
Abstract
Studies were undertaken in 33 uremic patients with or without hypertension, 11 normal subjects, and 15 essential hypertensive patients to assess cardiac hemodynamics, plasma volume, extracellular fluid volume, and peripheral renin levels. Cardiac output and intraarterial blood pressure were measured and peripheral vascular resistance index calculated.
These studies suggest that uremic hypertension with normal renin values and hypervolemia is hemodynamically sustained by an increase in peripheral resistance rather than by an increased cardiac output. The renin angiotensin system plays a secondary role as compared to overexpansion in the genesis of hypertension in normoreninemic uremic hypertension.
(Arch Intern Med 136:17-23, 1976)
Author Affiliations
From the Renal Section, Medical Service and Renal-Hypertension Research Laboratory, General Medical Research Laboratories, San Juan Veterans Administration Center, and Department of Medicine, University of Puerto Rico School of Medicine, San Juan.
Footnotes
Received for publication Oct 22, 1974; accepted March 17, 1975.
Read before the Seventh World Congress of Cardiology, Buenos Aires, Sept 3, 1974, and the Sixth International Congress of Nephrology, Florence, Italy, June 1975.
Reprint requests to Box 4867, San Juan, Puerto Rico 00936 (Dr. Cangiano).
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