This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Leo J. Sioris, PharmD; Robert T. Weibert, PharmD; Paul R. Pentel, MD

Arch Intern Med. 1980;140(4):546-547.

Abstract
• The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.

(Arch Intern Med 140:546-547, 1980)

Author Affiliations
From the Departments of Emergency Medicine (Dr Sioris) and Internal Medicine (Dr Pentel), Hennepin County Medical Center and University of Minnesota School of Medicine and College of Pharmacy (Drs Sioris and Weibert), Minneapolis. Dr Weibert is now with the School of Pharmacy, University of California San Francisco-San Diego Program, San Diego.

Footnotes
Accepted for publication July 17, 1979.

Reprint requests to Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Ave, Minneapolis, MN 55415 (Dr Sioris).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Systematic Overview of Warfarin and Its Drug and Food Interactions
Holbrook et al.
Arch Intern Med 2005;165:1095-1106.
ABSTRACT | FULL TEXT  

Antibiotic Therapy for Musculoskeletal Infections
Mader et al.
JBJS 2001;83:1878-1890.
FULL TEXT