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Alexandra M. Levine, MD; Ronald L. Burkes, MD; Martin Walker, MD; Paul R. Meyer, MD; Parkash S. Gill, MD; Peter W. Nichols, MD; Ruth Dworsky, RN; John W. Parker, MD; Robert J. Lukes, MD

Arch Intern Med. 1985;145(3):479-481.

Abstract
• Opportunistic infections and malignant neoplasms have been described in homosexual men in association with immunologic abnormalities. We observed the development of malignant B-cell lymphomas in two homosexual men who had had a monogamous relationship for two years. Patient 1 had an aggressive, monoclonal, small, noncleaved, non-Burkitt's lymphoma ("undifferentiated lymphoma"), associated with severe immunocompromise. Patient 2 manifested a monoclonal, small, cleaved, follicular center cell lymphoma, with a follicular pattern, two months later. No common acute infection was detected. Staining for Epstein-Barr nuclear antigen in malignant tissue was negative in the second patient. However, the possibility of a transmissible agent as a causative factor cannot be excluded, and further study of similar patients is warranted.

(Arch Intern Med 1985;145:479-481)

Author Affiliations
From the Section of Hematology, Department of Medicine (Drs Levine, Burkes, Walker, and Gill and Ms Dworsky), and the Section of Hematopathology, Department of Pathology (Drs Meyer, Nichols, Parker, and Lukes), Los Angeles County—University of Southern California Medical Center, Los Angeles.

Footnotes
Accepted for publication July 17, 1984.

Reprint requests to Kenneth Norris Jr Cancer Hospital, 1441 Eastlake Ave, Room 162, Los Angeles, CA 90033 (Dr Levine).

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