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  Vol. 146 No. 11, November 1986 TABLE OF CONTENTS
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Thrombosis, Recurrent Fetal Loss, and Thrombocytopenia

Predictive Value of the Anticardiolipin Antibody Test

E. Nigel Harris, MPhil, MD, DM; John K. H. Chan, MRCP; Ronald A. Asherson, FRCP; Victor R. Aber, MSc, DIC; Azzudin E. Gharavi, MD; Graham R. V. Hughes, MD, FRCP

Arch Intern Med. 1986;146(11):2153-2156.


Abstract

• To determine the predictive value of the IgG anticardiolipin antibody (ACA) test for thrombosis, recurrent fetal loss, and thrombocytopenia, the clinical features of 121 patients with varying antibody levels were studied. When patients were grouped into high-positive, low-positive, and normal groups according to their ACA levels, there were strong statistical correlations with arterial thrombosis, venous thrombosis, fetal loss, thrombocytopenia, and a positive Coombs' test. At levels of 7 SD and above, the test was highly specific (>80%) and predictive (>70%) for thrombosis, thrombocytopenia, and recurrent fetal loss. This study suggests that the IgG ACA test may be a useful predictor for thrombosis, recurrent fetal loss, and thrombocytopenia in patients with autoimmune disorders.

(Arch Intern Med 1986;146:2153-2156)



Author Affiliations

From the Lupus/Arthritis Research Unit, The Rayne Institute, St Thomas Hospital, London.


Footnotes

Accepted for publication Feb 20, 1986.

Reprint requests to Lupus/Arthritis Research Laboratory, Rayne Institute, St Thomas Hospital, London SE1 7EH, England (Dr Harris).



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