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COMMENTS AND OPINIONS
Effects of Garlic on Cholesterol: Not Down But Not Out Either—Reply
Christopher Gardner, PhD;
Larry D. Lawson, PhD;
Eric Block, PhD
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In reply
We recently reported the effects of garlic products on blood lipids among adults with moderately elevated LDL-C in a placebo-controlled randomized controlled trial.1 These 3 products—dried powdered garlic, aged garlic extract, and mashed raw garlic—were extensively chemically characterized before and throughout the intervention.2 Monthly blood samples were collected for 6 months for 192 randomized participants (87%-90% retention per treatment group). None of these garlic products had statistically or clinically significant effects on LDL-C or plasma lipid concentrations. We believe that this trial successfully addressed the limitations of many previous trials examining possible effects of garlic on blood lipid levels.3-4
Maslin suggests that steam-distilled garlic oil, not used in our trial, could have yielded different, positive results. Raw garlic contains numerous compounds not found in garlic oil (eg, protein, glutamylcysteines, and fructans). Theoretically, some of these compounds could increase . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Effects of Garlic on Cholesterol: Not Down But Not Out Either
David Maslin
Arch Intern Med. 2008;168(1):111-112.
EXTRACT
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RELATED ARTICLE
Effect of Raw Garlic vs Commercial Garlic Supplements on Plasma Lipid Concentrations in Adults With Moderate Hypercholesterolemia: A Randomized Clinical Trial
Christopher D. Gardner, Larry D. Lawson, Eric Block, Lorraine M. Chatterjee, Alexandre Kiazand, Raymond R. Balise, and Helena C. Kraemer
Arch Intern Med. 2007;167(4):346-353.
ABSTRACT
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