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  Vol. 168 No. 11, June 9, 2008 TABLE OF CONTENTS
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COMMENTS AND OPINIONS
Intention-to-Treat Analysis May Better Represent the Actual Efficacy

Steven C. Vlad, MD; Michael P. LaValley, PhD

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Rooks et al1 report that patients with fibromyalgia syndrome experienced a meaningful improvement in physical function and well-being after undergoing a program of aerobic and flexibility exercise, strength training, and a self-help course (the Arthritis Foundation's Fibromyalgia Self-Help Course). This is a finding with important treatment implications for this difficult-to-treat syndrome.

The authors' conclusions were based on the findings of an analysis of subjects who completed treatment, and they did a laudable job of fully and transparently describing withdrawals. They also indicated that they performed an intention-to-treat analysis; however, the results of this do not appear to have been reported. The intention-to-treat result may be especially important. First, high dropout rates can destroy the similarities between treatment groups that result from randomization and produce overestimates of the effects of an intervention.2 Because this trial had a high dropout rate (35%), the results . . . [Full Text of this Article]


AUTHOR INFORMATION

RELATED ARTICLE

Group Exercise, Education, and Combination Self-management in Women With Fibromyalgia: A Randomized Trial
Daniel S. Rooks, Shiva Gautam, Matthew Romeling, Martha L. Cross, Diana Stratigakis, Brittany Evans, Don L. Goldenberg, Maura D. Iversen, and Jeffrey N. Katz
Arch Intern Med. 2007;167(20):2192-2200.
ABSTRACT | FULL TEXT  






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