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Mario Tumbarello, MD; Brunella Posteraro, PhD; Enrico M. Trecarichi, MD; Maurizio Sanguinetti, MD

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We read with interest the article by Lee et al,¹ who conducted a case-case-control study to evaluate risk factors for fungemia caused by fluconazole-resistant Candida glabrata. The authors identified previous fluconazole use (and linezolid use) as a significant risk factor for fluconazole-resistant C glabrata fungemia, whereas cefepime and metronidazole use were independent risk factors for fluconazole-susceptible C glabrata fungemia.

Although with a smaller number of patients, a similar investigation with the same study design was previously carried out by our group.² In accordance with Lee et al,¹ our study had identified prior fluconazole exposure as the most important predisposing factor for subsequent C glabrata fungemia due to a less-susceptible isolate. We found that diabetes mellitus and central venous catheters were other independent risk factors for fungemia caused by a fluconazole–less-susceptible isolate, whereas previous surgery and central . . . [Full Text of this Article]

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Risk Factors for Fluconazole-Resistant Candida glabrata Bloodstream Infections
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Fluconazole Use as an Important Risk Factor in the Emergence of Fluconazole-Resistant Candida glabrata Fungemia—Reply
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