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COMMENTS AND OPINIONS
Fluconazole Use as an Important Risk Factor in the Emergence of Fluconazole-Resistant Candida glabrata Fungemia—Reply
Ingi Lee, MD, MSCE;
Neil O. Fishman, MD;
Theoklis E. Zaoutis, MD, MSCE;
Knashawn H. Morales, ScD;
Mark G. Weiner, MD;
Marie Synnestvedt, PhD;
Irving Nachamkin, DrPH, MPH;
Ebbing Lautenbach, MD, MPH, MSCE
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In reply
We thank Tumbarello and colleagues for their insightful comments. Their article evaluated risk factors, antifungal treatment, and outcomes in 14 patients with fluconazole–less-susceptible Candida glabrata bloodstream infections and 21 patients with fluconazole-susceptible C glabrata bloodstream infections.1 Similar to our results, the authors identified fluconazole use as a significant risk factor for fluconazole–less-susceptible C glabrata isolates. This provides further evidence supporting the role of fluconazole use in the emergence of fluconazole resistance. Their study additionally identified diabetes mellitus as an independent risk factor for fluconazole–less-susceptible isolates, while surgery was found to be an independent risk factor for fluconazole-susceptible isolates. Central venous catheter use was found to be a significant risk factor in both analyses, suggesting that . . . [Full Text of this Article]
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RELATED LETTER
Fluconazole Use as an Important Risk Factor in the Emergence of Fluconazole-Resistant Candida glabrata Fungemia
Mario Tumbarello, Brunella Posteraro, Enrico M. Trecarichi, and Maurizio Sanguinetti
Arch Intern Med. 2009;169(15):1444-1445.
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