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Beatrice Golomb, MD, PhD

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In a previous issue of the Archives, Giovannucci et al¹ linked higher vitamin D levels to lower cardiac risk. We surmised that the "contradictory" neutral finding for vitamin D + calcium supplementation (calcium carbonate, 500 mg as elemental calcium, with cholecalciferol [vitamin D₃], 200 IU twice daily) against myocardial infarction (MI) risk in the large WHI trial² might be speculated to arise from benefits of vitamin D against MI risk being offset by harms arising from the calcium with which it was given.³

Glaser challenges this on grounds that (1) vitamin D doses given in WHI were not high; (2) vitamin D supplementation variably raises vitamin D levels and other determinants play a role; and (3), in any case, findings based on natural source vitamins in observational studies need not be replicated with supplements.

These assertions are certainly true and important but immaterial to . . . [Full Text of this Article]

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RELATED LETTER

Vitamin D Supplements vs Plasma Level
John H. Glaser
Arch Intern Med. 2009;169(16):1536.
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